BrianC
You can setup filters to auto assign based on criteria and you can setup auto-assignment via Help Topics. You cannot force auto-assignment as in make that field required without modifying the codebase.
You can also configure the system to where it automatically claims the Ticket for the Responding Agent (via Claim on Response setting). Meaning, if a Ticket isn’t assigned and an Agent replies they will claim the ticket (get assigned).
Cheers.