In order for anybody to provide a reasonable answer, we'd need to know the web server software and version, PHP version, etc... (all under Admin -> Dashboard -> Information). See https://forum.osticket.com/d/89131-please-read-before-requesting-assistance for other useful info that may help.
Also, does your system meet the requirements in https://osticket.com/faq/ ? If you're running an older version of PHP as an example, you'd need to update.