jsbanjo While I haven't been using osTicket for as long as ntozier has, the OS is really all down to personal preference. osTicket is 'just' a bunch of webpages, so whatever you feel more comfortable in setting up and using a web server and MySQL database is the one to go for. Personally, I've always been a fan of Fedora but you do have to be careful with upgrades as Fedora tends to go bleeding edge and get new versions of PHP and such that aren't supported in the current version of osTicket much quicker than other distros.
CLI all the way 🤓 (again, this is just down to preference and makes absolutely no difference to how osTicket performs)