RickxZen
We are using for 2 departments and it's been working fine for us.
If you are looking to customize a lot, it's best to set up standalone
If you are looking to just add the second Department as their own support email address, Agent(s), Help Topic(s), SLA, etc.. basic separation, then choosing one installing would be ideal, it does save time and resources, also it's great for transferring ticket between departments, or Agent who works in both department and one URL.
so you will have to plan out your needs and process how you see your support ticket functioning, then create a map of it, test it and then implement it.