Assuming this is where bugs are reported as I can find no bug forum or tracker...
When changing settings in Settings -> Tickets -> Autoresponder you're given an error "Unable to update settings. Correct any errors below and try again." There are no errors below, and the settings are in fact saved.
Fresh install:
osTicket Version v1.12.2 (a5d898b) — Up to date
Web Server Software Apache/2.4.29 (Ubuntu)
MySQL Version 5.7.27
PHP Version 7.2.19-0ubuntu0.18.04.2