If you want to re-purpose Help Topics to be the first level then yes.
ie make your help topics:
Region A
Region B
Region C
Then you can make and add custom forms to each Help Topic.
Each form would then have a list of the countries in the region.
So Region A would have a list called "Region A"
The list would have:
country 1
country 2
country 3
etc.
Otherwise there isn't a way to do what your asking using the UI currently. And well you would give up meaningful Help Topics in favor of Regions / Country.