skip creating ticket based on subject

We are using wetransfer to send stuff and wetranfer send a autorespons when sending is compleet, downloaded, or when you using a wrong emailadress.

Is it possible to skip creating a ticket based on subject (or part of the subject)?

In this example, I want to skip creating a ticket on the first two respons emails, but want to create a ticket in the last one.

Thanks,

Mrtpols