Osticket is very slow when posting a reply. the reason is that php mail function takes too much time. So I use the linux crond service, but it seems not useful.
My question is how to send mail use cron only, not at the time click reply button?
OSTicket does not support message queueing for sending in batches later. I honestly cannot think of any web based program that does what you are describing. It utilizes either phpmail, or connects directly to an email server to send its mail.