odydahary
There’s no telling without you debugging further. Could be slow/long running database queries, could be the server struggling to serve content, database doesn’t have enough resources since the db has grown, etc. There are various things you can do to further debug including enabling MySQL/MariaDB slow query logs, tracking server request times to specific resources, monitoring server load and resource usage, tracking database resource/process usage, etc.
As far as the database goes here in the past 2 years or so it appears MySQL 8.0+ is way better out of the box (especially in performance) compared to MariaDB. MariaDB usually requires optimizations that most people typically don’t do. Not our experience personally with our severs/setups but with users in this forum this seems to be the general synopsis.
Cheers.