Problem fixed, the hint with the logs was the solution. I had already increased the max_input_vars from 1000 to 3000, but missed to restart the service. Since the error message in the logs remained even after the increase, I have then made up for it. Lo and behold, it works now. The force be with you! Mega cool support by the way, would not have expected such a quick response. Small insider question, when will there be 2.0, new UI and all the cool changes ;-)
Frank
PHP Logs
[21-Apr-2023 20:38:35] WARNING: [pool app.crashdirect.de] child 2952129 said into stderr: "PHP message: PHP Warning: Unknown: Input variables exceeded 1000. To increase the limit change max_input_vars in php.ini. in Unknown on line 0"