#@$#! - I walked away from the keyboard for a few minutes and something popped into my head. Given my issue with LDAP lookups not working on PHP 8.1 (https://forum.osticket.com/d/101561-ldap-doesnt-work-after-update/18) I thought... what about the PHP version?
I switched the site to PHP 8.1, the "Save Changes" worked without any issue, and when I ran the cron job at osticket\api\cron.php, it fetched email.
Then, to see what would happen, I switched it back to PHP 8.0. I disabled and re-enabled the email fetching and there was no error displayed. However running the Cron job didn't fetch emails.
So I switched back to PHP 8,1 and tried again. Still didn't fetch emails.
So running under 8.1, I disabled and re-enabled email fetching for the account.
The I re-ran the cron job and it fetched the emails.
EDIT: I just realized the command I used to call the CRON while running under PHP 8.0 was pointed at the PHP 8.1 directory, for what that is worth as far as it not fetching under 8.0. Still doesn't explain why I had to disable/reenable to get it work after switching the site back to 8.1