Abrito
Depends on what's happening. You should enable MySQL Slow Query Logs, set the execution time to like 2 seconds, and review the slow queries. This will give us a better idea of what is actually being slow. Also, you should look at your server resources to see if anything is peaking when doing certain actions in the helpdesk.
Typically this can be due to having all of your attachments stored in the database which grows the database size dramatically (in most cases) and slows the database down. In this instance you can install the Attachments on the Filesystem plugin to store new attachments on the server (or configured drive) as well as offloading existing attachments in the database to the filesystem.
Cheers.
